Fluoroacetamide Toxic Leukodystrophy Treated by Butylphthalide: A Case Report with a Review of the Literature

Fluoroacetamide is a high effective rodenticide with broad spectrum. A series of toxic symptoms emerge such as nausea, vomiting with bloody vomitus, epigastric burning, dizziness, headache, fatigue, face muscle twitching, dysphoria, expiratory dyspnea, hypotension, recurrent epigastric burning, general paroxysmal and tonic convulsion. Fluoroacetamide toxic leukodystrophy was rarely reported. Here, we report a case of fluoroacetamide toxic leukodystrophy treated by Butylphthalide and review the literature. A 22-year-old woman presented with a history of rodenticide toxic for about three days. Physical examination and brain MRI of the patient revealed leukodystrophy. After treated with Butylphthalide injection 50mg.d-1, energy mixture and multiplex vitamin for 7 days, symptoms such as staring, speaking, and limb twitching disappeared. Brain MRI was approximately normal in a week and completely normal following up 3 months later. We review the previously published cases of fluoroacetamide poisoning, and discuss the principal diagnosis and treatments of fluoroacetamide poisoning.